Acridones Are Highly Potent Inhibitors of Toxoplasma gondii Tachyzoites.
ACS Infect Dis
; 7(7): 1877-1884, 2021 07 09.
Article
em En
| MEDLINE
| ID: mdl-33723998
ABSTRACT
Acridone derivatives, which have been shown to have in vitro and in vivo activity against Plasmodium spp, inhibit Toxoplasma gondii proliferation at picomolar concentrations. Using enzymatic assays, we show that acridones inhibit both T. gondii cytochrome bc1 and dihydroorotate dehydrogenase and identify acridones that bind preferentially to the Qi site of cytochrome bc1. We identify acridones that have efficacy in a murine model of systemic toxoplasmosis. Acridones have potent activity against T. gondii and represent a promising new class of preclinical compounds.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Parasitos
/
Toxoplasma
/
Toxoplasmose
Limite:
Animals
Idioma:
En
Revista:
ACS Infect Dis
Ano de publicação:
2021
Tipo de documento:
Article