The abscopal effect of radiation therapy.
Future Oncol
; 17(13): 1683-1694, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33726502
ABSTRACT
Radiation therapy (RT) in some cases results in a systemic anticancer response known as the abscopal effect. Multiple hypotheses support the role of immune activation initiated by RT-induced DNA damage. Optimal radiation dose is necessary to promote the cGAS-STING pathway in response to radiation and initiate an IFN-1 signaling cascade that promotes the maturation and migration of dendritic cells to facilitate antigen presentation and stimulation of cytotoxic T cells. T cells then exert a targeted response throughout the body at areas not subjected to RT. These effects are further augmented through the use of immunotherapeutic drugs resulting in increased T-cell activity. Tumor-infiltrating lymphocyte presence and TREX1, KPNA2 and p53 signal expression are being explored as prognostic biomarkers.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Quimiorradioterapia
/
Inibidores de Checkpoint Imunológico
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2021
Tipo de documento:
Article