Histone lactylation drives oncogenesis by facilitating m<sup>6</sup>A reader protein YTHDF2 expression in ocular melanoma.

Yu, Jie; Chai, Peiwei; Xie, Minyue; Ge, Shengfang; Ruan, Jing; Fan, Xianqun; Jia, Renbing

Histone lactylation drives oncogenesis by facilitating m⁶A reader protein YTHDF2 expression in ocular melanoma.

Yu, Jie; Chai, Peiwei; Xie, Minyue; Ge, Shengfang; Ruan, Jing; Fan, Xianqun; Jia, Renbing.

Afiliação

Yu J; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.
Chai P; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.
Xie M; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.
Ge S; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.
Ruan J; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.
Fan X; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.
Jia R; Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China. renbingjia@sjtu.edu.cn.

Genome Biol ; 22(1): 85, 2021 03 16.

Article em En | MEDLINE | ID: mdl-33726814

Assuntos

Adenosina/análogos & derivados; Transformação Celular Neoplásica/genética; Epigênese Genética; Neoplasias Oculares/genética; Histonas/metabolismo; Melanoma/genética; Proteínas de Ligação a RNA/genética; Acetilação; Adenosina/metabolismo; Linhagem Celular Tumoral; Transformação Celular Neoplásica/metabolismo; Neoplasias Oculares/metabolismo; Neoplasias Oculares/patologia; Regulação Neoplásica da Expressão Gênica; Humanos; Melanoma/metabolismo; Melanoma/patologia; Modelos Biológicos; Oncogenes; Proteínas Circadianas Period; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Proteínas de Ligação a RNA/metabolismo; Células Tumorais Cultivadas; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

Histone lactylation; Ocular melanoma; Transcriptional activation; YTHDF2; m6A

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Adenosina / Transformação Celular Neoplásica / Proteínas de Ligação a RNA / Epigênese Genética / Neoplasias Oculares / Melanoma Limite: Humans Idioma: En Revista: Genome Biol Ano de publicação: 2021 Tipo de documento: Article

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