Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation.

Wang, Wenjie; Liu, Luyao; Hui, Xiaoying; Wang, Ying; Ying, Wenjing; Zhou, Qinhua; Hou, Jia; Yang, Mi; Sun, Bijun; Sun, Jinqiao; Wang, Xiaochuan

Wang, Wenjie; Liu, Luyao; Hui, Xiaoying; Wang, Ying; Ying, Wenjing; Zhou, Qinhua; Hou, Jia; Yang, Mi; Sun, Bijun; Sun, Jinqiao; Wang, Xiaochuan.

Afiliação

Wang W; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Liu L; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Hui X; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Wang Y; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Ying W; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Zhou Q; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Hou J; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Yang M; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Sun B; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Sun J; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. jinqiaosun@fudan.edu.cn.
Wang X; Department of Clinical Immunology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. xchwang@shmu.edu.cn.

BMC Immunol ; 22(1): 19, 2021 03 17.

Article em En | MEDLINE | ID: mdl-33731004

Assuntos

Anticorpos Monoclonais Humanizados/uso terapêutico; Pancitopenia/tratamento farmacológico; Pancitopenia/genética; Fator de Transcrição STAT3/genética; Adolescente; Linfócitos B/efeitos dos fármacos; Feminino; Mutação com Ganho de Função; Humanos; Interleucina-6/sangue; Subpopulações de Linfócitos/efeitos dos fármacos; Pancitopenia/imunologia; Linfócitos T/efeitos dos fármacos; Resultado do Tratamento

Palavras-chave

Gain-of-function mutations; Immune Dysregulation; STAT3 transcription factor; Tocilizumab

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Pancitopenia / Fator de Transcrição STAT3 / Anticorpos Monoclonais Humanizados Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans Idioma: En Revista: BMC Immunol Ano de publicação: 2021 Tipo de documento: Article

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