Your browser doesn't support javascript.
loading
Intelligence decline across major depressive disorder, bipolar disorder, and schizophrenia.
Ohi, Kazutaka; Takai, Kentaro; Sugiyama, Shunsuke; Kitagawa, Hiromi; Kataoka, Yuzuru; Soda, Midori; Kitaichi, Kiyoyuki; Kawasaki, Yasuhiro; Ito, Munechika; Shioiri, Toshiki.
Afiliação
  • Ohi K; Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Takai K; Department of General Internal Medicine, Kanazawa Medical University, Kahoku, Japan.
  • Sugiyama S; Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Kitagawa H; Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Kataoka Y; Department of Psychiatry and Psychotherapy, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Soda M; Department of Neuropsychiatry, Kanazawa Medical University, Kahoku, Japan.
  • Kitaichi K; Laboratory of Pharmaceutics, Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
  • Kawasaki Y; Laboratory of Pharmaceutics, Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
  • Ito M; Department of Neuropsychiatry, Kanazawa Medical University, Kahoku, Japan.
  • Shioiri T; Faculty of Education, Gifu University, Gifu, Japan.
CNS Spectr ; : 1-7, 2021 Mar 18.
Article em En | MEDLINE | ID: mdl-33731244
BACKGROUND: Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are associated with impaired intelligence that predicts poor functional outcomes. However, little is known regarding the extent and severity of intelligence decline, that is, decreased present intelligence quotient (IQ) relative to premorbid levels, across psychiatric disorders and which clinical characteristics affect the decline. METHODS: Premorbid IQ, present IQ, and intelligence decline were compared across patients with MDD (n = 45), BD (n = 30), and SCZ (n = 139), and healthy controls (HCs; n = 135). Furthermore, we investigated which factors contribute to the intelligence decline in each diagnostic group. RESULTS: Significant differences were observed in premorbid IQ, present IQ, and intelligence decline across the diagnostic groups. Patients with each psychiatric disorder displayed lower premorbid and present IQ and more intelligence decline than HCs. Patients with SCZ displayed lower premorbid and present IQ and more intelligence decline than patients with MDD and BD, while there were no significant differences between patients with MDD and BD. When patients with BD were divided based on bipolar I disorder (BD-I) and bipolar II disorder (BD-II), degrees of intelligence decline were similar between MDD and BD-II and between BD-I and SCZ. Lower educational attainment was correlated with a greater degree of intelligence decline in patients with SCZ and BD but not MDD. CONCLUSIONS: These findings confirm that although all psychiatric disorders display intelligence decline, the severity of intelligence decline differs across psychiatric disorders (SCZ, BD-I > BD-II, MDD > HCs). Higher educational attainment as cognitive reserve contributes to protection against intelligence decline in BD and SCZ.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: CNS Spectr Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: CNS Spectr Ano de publicação: 2021 Tipo de documento: Article