The membrane axis of Alzheimer's nanomedicine.
Adv Nanobiomed Res
; 1(1)2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-33748816
ABSTRACT
Alzheimer's disease (AD) is a major neurological disorder impairing its carrier's cognitive function, memory and lifespan. While the development of AD nanomedicine is still nascent, the field is evolving into a new scientific frontier driven by the diverse physicochemical properties and theranostic potential of nanomaterials and nanocomposites. Characteristic to the AD pathology is the deposition of amyloid plaques and tangles of amyloid beta (Aß) and tau, whose aggregation kinetics may be curbed by nanoparticle inhibitors via sequence-specific targeting or nonspecific interactions with the amyloidogenic proteins. As literature implicates cell membrane as a culprit in AD pathogenesis, here we summarize the membrane axis of AD nanomedicine and present a new rationale that the field development may greatly benefit from harnessing our existing knowledge of Aß-membrane interaction, nanoparticle-membrane interaction and Aß-nanoparticle interaction.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Adv Nanobiomed Res
Ano de publicação:
2021
Tipo de documento:
Article