A Dual Target-Directed Single Domain-Based Fusion Protein Against Interleukin-6 Receptor Decelerate Experimental Arthritis Progression Via Modulating JNK Expression.

Chen, Xiaole; Bian, Yize; Xie, Yongqing; Zheng, Ningning; Nie, Kaimei; Liu, Rui; Yan, Mengru; Luo, Hongbin; Wang, He; Yang, Juhua; Zhang, Nanwen

Chen, Xiaole; Bian, Yize; Xie, Yongqing; Zheng, Ningning; Nie, Kaimei; Liu, Rui; Yan, Mengru; Luo, Hongbin; Wang, He; Yang, Juhua; Zhang, Nanwen.

Afiliação

Chen X; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Bian Y; Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, Fujian, China.
Xie Y; Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Zheng N; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Nie K; Department of Pharmacology, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Liu R; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Yan M; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Luo H; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Wang H; Department of Orthopedics,The First Affiliated Hospital of Fujian Medical University, Fujian, Fuzhou, China.
Yang J; School of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China. hwang11@qub.ac.uk.
Zhang N; Department of Bioengineering and Biopharmaceutics, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China. Julian_yang@fjmu.edu.cn.

Inflammation ; 44(4): 1620-1628, 2021 Aug.

Article em En | MEDLINE | ID: mdl-33751358

Assuntos

Anti-Inflamatórios/imunologia; Artrite Experimental/tratamento farmacológico; Interleucina-6/antagonistas & inibidores; Albumina Sérica Humana/antagonistas & inibidores; Anticorpos de Domínio Único/imunologia; Animais; Anti-Inflamatórios/uso terapêutico; Especificidade de Anticorpos; Artrite Experimental/imunologia; Citocinas/metabolismo; DNA Complementar/genética; Dexametasona/uso terapêutico; Avaliação Pré-Clínica de Medicamentos; Indução Enzimática/efeitos dos fármacos; Humanos; Interleucina-6/imunologia; Lipopolissacarídeos/toxicidade; MAP Quinase Quinase 4/biossíntese; MAP Quinase Quinase 4/genética; Camundongos; Modelos Moleculares; Terapia de Alvo Molecular; Óxido Nítrico/metabolismo; Conformação Proteica; Células RAW 264.7; Distribuição Aleatória; Ratos; Ratos Sprague-Dawley; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/imunologia; Albumina Sérica Humana/imunologia; Anticorpos de Domínio Único/genética

Palavras-chave

fusion protein; inflammatory cytokine; interleukin 6 receptor; prokaryotic expression system; rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Interleucina-6 / Anticorpos de Domínio Único / Albumina Sérica Humana / Anti-Inflamatórios Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Inflammation Ano de publicação: 2021 Tipo de documento: Article

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