Kinetochore assembly throughout the cell cycle.
Semin Cell Dev Biol
; 117: 62-74, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-33753005
ABSTRACT
The kinetochore plays an essential role in facilitating chromosome segregation during cell division. This massive protein complex assembles onto the centromere of chromosomes and enables their attachment to spindle microtubules during mitosis. The kinetochore also functions as a signaling hub to regulate cell cycle progression, and is crucial to ensuring the fidelity of chromosome segregation. Despite the fact that kinetochores are large and robust molecular assemblies, they are also highly dynamic structures that undergo structural and organizational changes throughout the cell cycle. This review will highlight our current understanding of kinetochore structure and function, focusing on the dynamic processes that underlie kinetochore assembly.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cinetocoros
/
Proteínas de Ciclo Celular
/
Fuso Acromático
Limite:
Humans
Idioma:
En
Revista:
Semin Cell Dev Biol
Ano de publicação:
2021
Tipo de documento:
Article