Platforms for Personalized Polytherapeutics Discovery in COVID-19.
J Mol Biol
; 433(10): 166945, 2021 05 14.
Article
em En
| MEDLINE
| ID: mdl-33753053
ABSTRACT
The COVID-19 pandemic entered its third and most intense to date wave of infections in November 2020. This perspective article describes how combination therapies (polytherapeutics) are a needed focus for helping battle the severity of complications from SARS-CoV-2 infection. It outlines the types of systems that are needed for fast and efficient combinatorial assessment of therapeutic candidates. Proposed are micro-physiological systems using human iPSC as a format for tissue-specific modeling of infection, the use of gene-humanized zebrafish and C. elegans for combinatorial drug screens due to the animals being addressable in liquid multi-well formats, and the use of engineered pseudo-typing systems to safely model infection in the transgenic animals and engineered tissue systems.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Modelos Animais de Doenças
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Avaliação Pré-Clínica de Medicamentos
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Células-Tronco Pluripotentes Induzidas
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Tratamento Farmacológico da COVID-19
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Mol Biol
Ano de publicação:
2021
Tipo de documento:
Article