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Prediction of in vivo supersaturation and precipitation of poorly water-soluble drugs: Achievements and aspirations.
Thakral, Naveen K; Meister, Eva; Jankovsky, Corinne; Li, Li; Schwabe, Robert; Luo, Laibin; Chen, Shirlynn.
Afiliação
  • Thakral NK; Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States. Electronic address: naveen.thakral@boehringer-ingelheim.com.
  • Meister E; Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
  • Jankovsky C; Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
  • Li L; Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 4849 Calhoun Road, Houston, TX 77204, United States.
  • Schwabe R; Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
  • Luo L; Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
  • Chen S; Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
Int J Pharm ; 600: 120505, 2021 May 01.
Article em En | MEDLINE | ID: mdl-33753162
This review focuses on options available to a pharmaceutical scientist to predict in vivo supersaturation and precipitation of poorly water-soluble drugs. As no single device or system can simulate the complex gastrointestinal environment, a combination of appropriate in vitro tools may be utilized to get optimal predictive information. To address the empirical issues encountered during small-scale and full-scale in vitro predictive testing, theoretical background and relevant case studies are discussed. The practical considerations for selection of appropriate tools at various stages of drug development are recommended. Upcoming technologies that have potential to further reduce in vivo studies and expedite the drug development process are also discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Água Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Pharm Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Água Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Int J Pharm Ano de publicação: 2021 Tipo de documento: Article