Fabrication of a Dual-Action Membrane with Both Antibacterial and Anticoagulant Properties via Cationic Polyelectrolyte-Induced Phase Separation.
ACS Appl Mater Interfaces
; 13(13): 14938-14950, 2021 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-33775092
ABSTRACT
The development of microorganisms and formation of thrombus on a biomaterial surface can seriously lead to device failure and threaten human health. Nonetheless, a surface that has both antibacterial and anticoagulant properties has scarcely been developed. Herein, a novel dual-action membrane composed of polyethersulfone (PES) bulk material and a hydrophilic anionic poly-2-acrylamido-2-methylpropanesulfonic acid (PAMPS) polymer has been prepared via the cationic antibacterial agent poly(hexamethylene biguanide) (PHMB)-induced phase separation technique. Interestingly, the resultant membrane can offer tunable antibacterial and anticoagulant properties, while maintaining satisfactory permeability and greatly increasing selectivity. The membrane also shows excellent hydrophilicity, a well-defined porous surface, and cross section with a sponge gradient structure. Furthermore, the PHMB-PAMPS complex formed on the membrane surface displays outstanding long-term stability, which is crucial for further practical applications. More importantly, the hollow fiber membrane fabricated by the cationic polyelectrolyte-induced phase separation technique confirms its capability to control the membrane permeability (257.4 L·m-2·h-1·bar-1) and selectivity (95.9%) without destroying the membrane structure. The present work opens a straightforward and efficient avenue for the rational design of a functional surface to fight biomedical material-associated infections.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
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Transição de Fase
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Polieletrólitos
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Membranas Artificiais
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Antibacterianos
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Anticoagulantes
Limite:
Animals
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Humans
Idioma:
En
Revista:
ACS Appl Mater Interfaces
Ano de publicação:
2021
Tipo de documento:
Article