Prenatal developmental toxicity studies on fumes from oxidised asphalt (OA) in the rat.
Reprod Toxicol
; 102: 67-79, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33781938
The prenatal developmental toxicity of the fumes of oxidised asphalt (OA) was tested by nose-only inhalation in the rat. The test material was generated by collecting fumes from the headspace of storage tanks filled with OA. The composition of these fumes was matched to fumes sampled at a workplace where the same OA was applied in a pour-and-roll operation, representing occupational exposure with high concentrations of fumes to not underestimate the possible hazard. In the main study, dams were exposed to 0, 53, 158 and 536â¯mg/m3 of fume (as total organic mass), for 6â¯h/day for 19 days p.c. The maternal NOAEC was 53â¯mg/m³ (lowest dose tested). In the high-dose group treatment-related effects on body weight gain were seen. In the mid- and high-dose groups treatment-related effects on food consumption, lung weights, and histopathological changes in lungs and the upper respiratory tract were observed. The NOAEC for prenatal developmental toxicity was 536â¯mg/m³ since no exposure-related effects were found in any of the exposure groups for any of the investigated reproductive endpoints. Furthermore, nose-only exposure to OA fumes in concentrations up to 536â¯mg/m³ from days 1-19 p.c. did not induce any significant fetal abnormalities.
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Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
12_ODS3_hazardous_contamination
Base de dados:
MEDLINE
Assunto principal:
Exposição por Inalação
/
Hidrocarbonetos
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Reprod Toxicol
Ano de publicação:
2021
Tipo de documento:
Article