Bioelectronics in the brain-gut axis: focus on inflammatory bowel disease (IBD).
Int Immunol
; 33(6): 337-348, 2021 06 07.
Article
em En
| MEDLINE
| ID: mdl-33788920
ABSTRACT
Accumulating evidence shows that intestinal homeostasis is mediated by cross-talk between the nervous system, enteric neurons and immune cells, together forming specialized neuroimmune units at distinct anatomical locations within the gut. In this review, we will particularly discuss how the intrinsic and extrinsic neuronal circuitry regulates macrophage function and phenotype in the gut during homeostasis and aberrant inflammation, such as observed in inflammatory bowel disease (IBD). Furthermore, we will provide an overview of basic and translational IBD research using these neuronal circuits as a novel therapeutic tool. Finally, we will highlight the different challenges ahead to make bioelectronic neuromodulation a standard treatment for intestinal immune-mediated diseases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Eixo Encéfalo-Intestino
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Inflamação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int Immunol
Ano de publicação:
2021
Tipo de documento:
Article