Inhibiting mTOR activity using AZD2014 increases autophagy in the mouse cerebral cortex.

Bensalem, Julien; Fourrier, Célia; Hein, Leanne K; Hassiotis, Sofia; Proud, Christopher G; Sargeant, Timothy J

Bensalem, Julien; Fourrier, Célia; Hein, Leanne K; Hassiotis, Sofia; Proud, Christopher G; Sargeant, Timothy J.

Afiliação

Bensalem J; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, Australia.
Fourrier C; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, Australia.
Hein LK; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, Australia.
Hassiotis S; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, Australia.
Proud CG; Nutrition, Diabetes and Gut Health, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, Australia.
Sargeant TJ; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, Australia. Electronic address: Tim.Sargeant@sahmri.com.

Neuropharmacology ; 190: 108541, 2021 06 01.

Article em En | MEDLINE | ID: mdl-33794244

Assuntos

Autofagia/efeitos dos fármacos; Benzamidas/farmacologia; Córtex Cerebral/efeitos dos fármacos; Inibidores de MTOR/farmacologia; Morfolinas/farmacologia; Pirimidinas/farmacologia; Animais; Proteínas de Fluorescência Verde/genética; Células HeLa; Humanos; Fígado/efeitos dos fármacos; Alvo Mecanístico do Complexo 1 de Rapamicina/antagonistas & inibidores; Camundongos; Camundongos Transgênicos; Proteínas Associadas aos Microtúbulos/efeitos dos fármacos; Proteínas Associadas aos Microtúbulos/metabolismo

Palavras-chave

AZD2014; Autophagy; Brain; HeLa cells; Lysosome; Mechanistic target of rapamycin kinase; TF-LC3; Vistusertib; mTOR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Autofagia / Benzamidas / Córtex Cerebral / Morfolinas / Inibidores de MTOR Limite: Animals / Humans Idioma: En Revista: Neuropharmacology Ano de publicação: 2021 Tipo de documento: Article

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