Reduced <i>USP22</i> Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.

Jeusset, Lucile M; Guppy, Brent J; Lichtensztejn, Zelda; McDonald, Darin; McManus, Kirk J

Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.

Jeusset, Lucile M; Guppy, Brent J; Lichtensztejn, Zelda; McDonald, Darin; McManus, Kirk J.

Afiliação

Jeusset LM; Research Institute in Oncology & Hematology, CancerCare Manitoba, Winnipeg, MB R3E0V9, Canada.
Guppy BJ; Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E0J9, Canada.
Lichtensztejn Z; Research Institute in Oncology & Hematology, CancerCare Manitoba, Winnipeg, MB R3E0V9, Canada.
McDonald D; Department of Biochemistry & Medical Genetics, University of Manitoba, Winnipeg, MB R3E0J9, Canada.
McManus KJ; Research Institute in Oncology & Hematology, CancerCare Manitoba, Winnipeg, MB R3E0V9, Canada.

Cancers (Basel) ; 13(5)2021 Mar 02.

Article em En | MEDLINE | ID: mdl-33801331

Palavras-chave

BUB1; H2B ubiquitination; H2Bub1; STED; USP22; cancer; chromatin compaction; chromosome instability; mitosis; quantitative imaging microscopy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2021 Tipo de documento: Article