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Late effects of radiation therapy in pediatric patients and survivorship.
Palmer, Joshua D; Tsang, Derek S; Tinkle, Christopher L; Olch, Arthur J; Kremer, Leontien C M; Ronckers, Cecile M; Gibbs, Iris C; Constine, Louis S.
Afiliação
  • Palmer JD; Department of Radiation Oncology, The James Cancer Hospital at the Ohio State University Wexner Medical Center and Nationwide Children's Hospital, Ohio, Columbus.
  • Tsang DS; Radiation Medicine Program, Princess Margaret Cancer Centre, Division of Haematology/Oncology, Hospital for Sick Children, University Health Network, Toronto, Canada.
  • Tinkle CL; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.
  • Olch AJ; Department of Radiation Oncology, Keck School of Medicine of USC and Children's' Hospital Los Angeles, Los Angeles, California.
  • Kremer LCM; Department of Pediatrics, Amsterdam UMC, Emma Children's Hospital, Amsterdam, the Netherlands.
  • Ronckers CM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Gibbs IC; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Constine LS; Brandenburg Medical School, Institute for Biostatistics and Registry Research, Neuruppin, Germany.
Pediatr Blood Cancer ; 68 Suppl 2: e28349, 2021 05.
Article em En | MEDLINE | ID: mdl-33818893
Advances in multimodality therapy have led to childhood cancer cure rates over 80%. However, surgery, chemotherapy, and radiotherapy may lead to debilitating or even fatal long-term effects among childhood survivors beyond those inflicted by the primary disease process. It is critical to understand, mitigate, and prevent these late effects of cancer therapy to improve the quality of life of childhood cancer survivors. This review summarizes the various late effects of radiotherapy and acknowledges the Pediatric Normal Tissue Effects in the Clinic (PENTEC), an international collaboration that is systematically analyzing the association between radiation treatment dose/volume and consequential organ toxicities, in developing children as a basis to formulate recommendations for clinical practice of pediatric radiation oncology. We also summarize initiatives for survivorship and surveillance of late normal tissue effects related to radiation therapy among long-term survivors of childhood cancer treated in the past.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Tolerância a Radiação / Radioterapia / Sobrevivência / Sobreviventes de Câncer / Neoplasias Tipo de estudo: Guideline Aspecto: Patient_preference Limite: Child / Humans Idioma: En Revista: Pediatr Blood Cancer Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Qualidade de Vida / Tolerância a Radiação / Radioterapia / Sobrevivência / Sobreviventes de Câncer / Neoplasias Tipo de estudo: Guideline Aspecto: Patient_preference Limite: Child / Humans Idioma: En Revista: Pediatr Blood Cancer Ano de publicação: 2021 Tipo de documento: Article