Regnase-1 is essential for B cell homeostasis to prevent immunopathology.
J Exp Med
; 218(5)2021 05 03.
Article
em En
| MEDLINE
| ID: mdl-33822844
ABSTRACT
Regnase-1 is an emerging regulator of immune responses with essential roles in the posttranscriptional control of immune cell activation. Regnase-1 is expressed in B cells; however, its B cell-specific functions remain unknown. Here, we demonstrate that Regnase-1 prevents severe autoimmune pathology and show its essential role in maintaining B cell homeostasis. Using Cre driver mice for ablation of Regnase-1 at various stages of B cell development, we demonstrate that loss of Regnase-1 leads to aberrant B cell activation and differentiation, resulting in systemic autoimmunity and early morbidity. The basis of these findings was informed by gene expression data revealing a regulatory role for Regnase-1 in the suppression of a transcriptional program that promotes B cell activation, survival, and differentiation. Overall, our study shows that Regnase-1 exerts critical control of B cell activation, which is required for prevention of immunopathology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ribonucleases
/
Linfócitos B
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Ativação Linfocitária
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Autoimunidade
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Homeostase
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2021
Tipo de documento:
Article