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Genetic substructure and complex demographic history of South African Bantu speakers.
Sengupta, Dhriti; Choudhury, Ananyo; Fortes-Lima, Cesar; Aron, Shaun; Whitelaw, Gavin; Bostoen, Koen; Gunnink, Hilde; Chousou-Polydouri, Natalia; Delius, Peter; Tollman, Stephen; Gómez-Olivé, F Xavier; Norris, Shane; Mashinya, Felistas; Alberts, Marianne; Hazelhurst, Scott; Schlebusch, Carina M; Ramsay, Michèle.
Afiliação
  • Sengupta D; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Choudhury A; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Fortes-Lima C; Human Evolution, Department of Organismal Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden.
  • Aron S; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Whitelaw G; KwaZulu-Natal Museum, Pietermaritzburg, South Africa.
  • Bostoen K; School of Geography, Archaeology & Environmental Studies, University of the Witwatersrand, Johannesburg, South Africa.
  • Gunnink H; UGent Centre for Bantu Studies, Department of Languages and Cultures, Ghent University, Ghent, Belgium.
  • Chousou-Polydouri N; UGent Centre for Bantu Studies, Department of Languages and Cultures, Ghent University, Ghent, Belgium.
  • Delius P; Department of Comparative Linguistic Science and Center for the Interdisciplinary Study of Language Evolution, University of Zürich, Zürich, Switzerland.
  • Tollman S; Department of History, University of the Witwatersrand, Johannesburg, South Africa.
  • Gómez-Olivé FX; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Norris S; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Mashinya F; MRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Alberts M; Department of Pathology and Medical Sciences; School of Health Care Sciences, Faculty of Health Sciences, University of Limpopo, Polokwane, South Africa.
  • Schlebusch CM; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Ramsay M; School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa.
Nat Commun ; 12(1): 2080, 2021 04 07.
Article em En | MEDLINE | ID: mdl-33828095
South Eastern Bantu-speaking (SEB) groups constitute more than 80% of the population in South Africa. Despite clear linguistic and geographic diversity, the genetic differences between these groups have not been systematically investigated. Based on genome-wide data of over 5000 individuals, representing eight major SEB groups, we provide strong evidence for fine-scale population structure that broadly aligns with geographic distribution and is also congruent with linguistic phylogeny (separation of Nguni, Sotho-Tswana and Tsonga speakers). Although differential Khoe-San admixture plays a key role, the structure persists after Khoe-San ancestry-masking. The timing of admixture, levels of sex-biased gene flow and population size dynamics also highlight differences in the demographic histories of individual groups. The comparisons with five Iron Age farmer genomes further support genetic continuity over ~400 years in certain regions of the country. Simulated trait genome-wide association studies further show that the observed population structure could have major implications for biomedical genomics research in South Africa.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demografia / População Negra / Fluxo Gênico / Estudo de Associação Genômica Ampla / Idioma Tipo de estudo: Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Nat Commun Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Demografia / População Negra / Fluxo Gênico / Estudo de Associação Genômica Ampla / Idioma Tipo de estudo: Risk_factors_studies Aspecto: Determinantes_sociais_saude Limite: Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Nat Commun Ano de publicação: 2021 Tipo de documento: Article