Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2.

Liu, Rengyun; Tan, Jie; Shen, Xiaopei; Jiang, Ke; Wang, Chaoqun; Zhu, Guangwu; Xing, Mingzhao

Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2.

Liu, Rengyun; Tan, Jie; Shen, Xiaopei; Jiang, Ke; Wang, Chaoqun; Zhu, Guangwu; Xing, Mingzhao.

Afiliação

Liu R; Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Tan J; Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Shen X; Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Jiang K; Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Wang C; Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Zhu G; Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Xing M; Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 mxing1@jhmi.edu.

Proc Natl Acad Sci U S A ; 118(11)2021 03 16.

Article em En | MEDLINE | ID: mdl-33836600

Assuntos

Apoptose/efeitos dos fármacos; Neoplasias/genética; Proteínas Proto-Oncogênicas c-fos/antagonistas & inibidores; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/genética; Survivina/genética; Telomerase/genética; Benzofenonas/farmacologia; Benzofenonas/uso terapêutico; Carcinogênese/efeitos dos fármacos; Carcinogênese/genética; Linhagem Celular Tumoral; Fator de Transcrição de Proteínas de Ligação GA/genética; Fator de Transcrição de Proteínas de Ligação GA/metabolismo; Regulação Neoplásica da Expressão Gênica; Humanos; Isoxazóis/farmacologia; Isoxazóis/uso terapêutico; Mutação; Neoplasias/tratamento farmacológico; Neoplasias/metabolismo; Regiões Promotoras Genéticas; Proteínas Proto-Oncogênicas c-fos/metabolismo; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/metabolismo; Transdução de Sinais/efeitos dos fármacos; Survivina/metabolismo; Telomerase/metabolismo

Palavras-chave

FOS; TERT promoter mutation; TRAIL-R2; apoptosis; survivin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-fos / Apoptose / Telomerase / Receptores do Ligante Indutor de Apoptose Relacionado a TNF / Survivina / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article

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