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The Current Management of Hepatorenal Syndrome-Acute Kidney Injury in the United States and the Potential of Terlipressin.
Flamm, Steven L; Brown, Kimberly; Wadei, Hani M; Brown, Robert S; Kugelmas, Marcelo; Samaniego-Picota, Milagros; Burra, Patrizia; Poordad, Fred; Saab, Sammy.
Afiliação
  • Flamm SL; Division of Gastroenterology and Hepatology Northwestern University Feinberg School of Medicine Chicago IL Division of Gastroenterology and Hepatology Transplant InstituteHenry Ford Hospital Detroit MI Department of Transplantation Mayo Clinic Jacksonville FL Department of Medicine, Division of Gastroenterology and Hepatology Weill Cornell Medicine New York NY Hepatology and Research South Denver Gastroenterology Englewood CO Department of Transplant Nephrology Henry Ford Health System Detroit M
Liver Transpl ; 27(8): 1191-1202, 2021 08.
Article em En | MEDLINE | ID: mdl-33848394
ABSTRACT
Acute kidney injury (AKI) in the setting of cirrhosis (hepatorenal syndrome [HRS]-AKI) is a severe and often fatal complication of end-stage liver disease. The goals of treatment are to reverse renal failure and prolong survival in patients who are critically ill. However, interventions have limited efficacy, and mortality rates remain high. In the United States, the mainstay of pharmacologic therapy consists of the off-label use of vasoconstrictive agents in combination with plasma expanders, a strategy that produces modest effects. Liver transplantation is the ultimate solution but is only an option in a minority of patients because contraindications to transplantation are common and organ availability is limited. Renal replacement therapy is a temporary option but is known to confer an extremely poor short-term prognosis in patients with HRS-AKI and at best serves as a bridge to liver transplantation for the minority of patients who are transplantation candidates. The high mortality rate associated with HRS-AKI in the United States is a reflection of the suboptimal standard of care. Improved therapeutic options to treat HRS-AKI are sought. Terlipressin is a drug approved in Europe for treatment of HRS-AKI and supported by recommendations for first-line therapy by some liver societies and experts around the world. This review article will discuss the substantial unmet medical need associated with HRS-AKI and the potential benefits if terlipressin was approved in the United States.
Assuntos

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Síndrome Hepatorrenal / Transplante de Fígado / Injúria Renal Aguda Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Liver Transpl Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Síndrome Hepatorrenal / Transplante de Fígado / Injúria Renal Aguda Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Revista: Liver Transpl Ano de publicação: 2021 Tipo de documento: Article