Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning.
J Pharmacol Sci
; 146(1): 29-32, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33858652
ABSTRACT
Hydroxyl radical (â¢OH) production in the rat striatum during carbon monoxide (CO) poisoning, which inhibits complex IV, was enhanced synergistically by malonate, a mitochondrial complex II inhibitor, but not N-methyl-4-phenylpyridinium or NaCN, complex I and IV inhibitors, respectively. No such enhancement appeared in the case of NaCN combined with malonate. Intrastriatal dopamine, which is involved in â¢OH production by malonate, did not synergistically enhance CO-induced â¢OH production. Diphenyleneiodonium, a nonselective NADPH oxidase inhibitor, partly suppressed the potentiation of CO-induced â¢OH production by malonate. Impairment of mitochondrial functions might potentiate oxidative stress and intensify CO toxicity in the brain.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Intoxicação por Monóxido de Carbono
/
Radical Hidroxila
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Corpo Estriado
Limite:
Animals
Idioma:
En
Revista:
J Pharmacol Sci
Ano de publicação:
2021
Tipo de documento:
Article