<i>N</i>-Adamantyl Phthalimidine: A New Thalidomide-like Drug That Lacks Cereblon Binding and Mitigates Neuronal and Synaptic Loss, Neuroinflammation, and Behavioral Deficits in Traumatic Brain Injury and LPS Challenge.

Hsueh, Shih Chang; Luo, Weiming; Tweedie, David; Kim, Dong Seok; Kim, Yu Kyung; Hwang, Inho; Gil, Jung-Eun; Han, Baek-Soo; Chiang, Yung-Hsiao; Selman, Warren; Hoffer, Barry J; Greig, Nigel H

N-Adamantyl Phthalimidine: A New Thalidomide-like Drug That Lacks Cereblon Binding and Mitigates Neuronal and Synaptic Loss, Neuroinflammation, and Behavioral Deficits in Traumatic Brain Injury and LPS Challenge.

Hsueh, Shih Chang; Luo, Weiming; Tweedie, David; Kim, Dong Seok; Kim, Yu Kyung; Hwang, Inho; Gil, Jung-Eun; Han, Baek-Soo; Chiang, Yung-Hsiao; Selman, Warren; Hoffer, Barry J; Greig, Nigel H.

Afiliação

Hsueh SC; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, Maryland 21224, United States.
Luo W; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, Maryland 21224, United States.
Tweedie D; Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program National Institute on Aging, NIH, Baltimore, Maryland 21224, United States.
Kim DS; AevisBio, Inc., Gaithersburg Maryland 20878, United States.
Kim YK; Aevis Bio, Inc., Daejeon 34141, Republic of Korea.
Hwang I; Aevis Bio, Inc., Daejeon 34141, Republic of Korea.
Gil JE; Aevis Bio, Inc., Daejeon 34141, Republic of Korea.
Han BS; Aevis Bio, Inc., Daejeon 34141, Republic of Korea.
Chiang YH; Research Center for Biodefence, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
Selman W; Department of Neurosurgery, Taipei Medical University Hospital, Taipei 110, Taiwan.
Hoffer BJ; Neuroscience Research Center, Taipei Medical University, Taipei 110, Taiwan.
Greig NH; Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan.

ACS Pharmacol Transl Sci ; 4(2): 980-1000, 2021 Apr 09.

Article em En | MEDLINE | ID: mdl-33860215

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Pharmacol Transl Sci Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Pharmacol Transl Sci Ano de publicação: 2021 Tipo de documento: Article