Total Synthesis of the Proposed Structure of Uncarialin A.
J Org Chem
; 86(9): 6927-6930, 2021 05 07.
Article
em En
| MEDLINE
| ID: mdl-33881855
ABSTRACT
The stereoselective total synthesis of the proposed structure of a potent serotonin 5-HT1A receptor agonist uncarialin A (1) is described. By employing the readily available meroquinene tert-butyl ester as the chiral synthon, the target structure has been prepared in a six-step linear sequence with a 17% overall yield. In comparison to the sample isolated from natural sources, the synthetic product shows significant spectral differences, strongly suggesting that the structure of the natural product should be revised.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ésteres
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2021
Tipo de documento:
Article