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Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
Arveseth, Corvin D; Happ, John T; Hedeen, Danielle S; Zhu, Ju-Fen; Capener, Jacob L; Klatt Shaw, Dana; Deshpande, Ishan; Liang, Jiahao; Xu, Jiewei; Stubben, Sara L; Nelson, Isaac B; Walker, Madison F; Kawakami, Kouki; Inoue, Asuka; Krogan, Nevan J; Grunwald, David J; Hüttenhain, Ruth; Manglik, Aashish; Myers, Benjamin R.
Afiliação
  • Arveseth CD; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Happ JT; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Hedeen DS; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Zhu JF; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Capener JL; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Klatt Shaw D; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Deshpande I; Department of Pharmaceutical Chemistry, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, California, United States of America.
  • Liang J; Department of Pharmaceutical Chemistry, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, California, United States of America.
  • Xu J; Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America.
  • Stubben SL; J. David Gladstone Institutes, San Francisco, California, United States of America.
  • Nelson IB; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Walker MF; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Kawakami K; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.
  • Krogan NJ; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.
  • Grunwald DJ; Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America.
  • Hüttenhain R; J. David Gladstone Institutes, San Francisco, California, United States of America.
  • Manglik A; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
  • Myers BR; Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America.
PLoS Biol ; 19(4): e3001191, 2021 04.
Article em En | MEDLINE | ID: mdl-33886552
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Hedgehog / Subunidades Catalíticas da Proteína Quinase Dependente de AMP Cíclico / Receptor Smoothened Limite: Animals / Humans Idioma: En Revista: PLoS Biol Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Hedgehog / Subunidades Catalíticas da Proteína Quinase Dependente de AMP Cíclico / Receptor Smoothened Limite: Animals / Humans Idioma: En Revista: PLoS Biol Ano de publicação: 2021 Tipo de documento: Article