The T-N tract involvement as a new prognostic factor for PORT in locally advanced oral cavity tumors.
Oral Dis
; 29(1): 128-137, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-33893695
ABSTRACT
OBJECTIVE:
The space comprised between tumor and neck lymph nodes (T-N tract) is one of the main routes of tumor spread in oral cavity tumors. Aim of the study was to investigate the impact of T-N tract involvement on the postoperative radiotherapy (PORT) outcomes. MATERIALS ANDMETHODS:
Patients (pts) treated between 2000 and 2016 with indication to PORT were retrospectively retrieved. Inclusion criteria were (a) locally advanced tumors of the oral cavity, (b) who received with indication to PORT (c) with a minimum follow-up of six months.RESULTS:
One hundred and fifty-seven pts met the inclusion criteria (136 pts treated with PORT and 21 pts not treated with PORT). In the PORT cohort, the T-N tract involvement had no impact on both OS (p = .09) and LRFS (p = .2). Among the non-PORT cohort, both OS (p = .007) and LRFS (p = .017) were worse for pts with positive T-N tract compared to those with negative T-N tract. PORT improved both OS (p = .008) and LRFS (p = .003) in pts with positive T-N tract but not in those with negative T-N tract (p = .36 and p = .37, respectively).CONCLUSIONS:
Our results suggest that involvement of T-N tract should be considered as prognostic factors informing the indication to PORT.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Oral Dis
Ano de publicação:
2023
Tipo de documento:
Article