Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1&#945;, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis.

Hepp, Michaël; Werion, Alexis; De Greef, Axel; de Ville de Goyet, Christine; de Bournonville, Marc; Behets, Catherine; Lengelé, Benoit; Daumerie, Chantal; Mourad, Michel; Ludgate, Marian; Many, Marie-Christine; Joris, Virginie; Craps, Julie

Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto's Thyroiditis.

Hepp, Michaël; Werion, Alexis; De Greef, Axel; de Ville de Goyet, Christine; de Bournonville, Marc; Behets, Catherine; Lengelé, Benoit; Daumerie, Chantal; Mourad, Michel; Ludgate, Marian; Many, Marie-Christine; Joris, Virginie; Craps, Julie.

Afiliação

Hepp M; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Werion A; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
De Greef A; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
de Ville de Goyet C; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
de Bournonville M; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Behets C; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Lengelé B; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Daumerie C; Endocrinology Department, Faculty of Medicine, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Mourad M; Surgery and Abdominal Transplantation-Utragendo Department, Faculty of Medicine, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Ludgate M; Thyroid Research Group, Division of Infection & Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Many MC; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Joris V; Pole of Pharmacology and Therapeutics, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Craps J; Pole of Morphology, Faculty of Medicine, Institute of Experimental and Clinical Research, Université Catholique de Louvain, B-1200 Brussels, Belgium.

Int J Mol Sci ; 22(8)2021 Apr 07.

Article em En | MEDLINE | ID: mdl-33916948

Assuntos

Doença de Hashimoto/etiologia; Doença de Hashimoto/metabolismo; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Estresse Oxidativo; Sirtuína 1/genética; Células Th1/imunologia; Células Th1/metabolismo; Fator A de Crescimento do Endotélio Vascular/genética; Adulto; Doenças Autoimunes/etiologia; Doenças Autoimunes/metabolismo; Autoimunidade/genética; Biomarcadores; Citocinas/genética; Citocinas/metabolismo; Feminino; Imunofluorescência; Regulação da Expressão Gênica; Doença de Hashimoto/diagnóstico; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Imuno-Histoquímica; Masculino; Pessoa de Meia-Idade; Modelos Biológicos; NADPH Oxidase 2/genética; NADPH Oxidase 2/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Sirtuína 1/metabolismo; Superóxido Dismutase-1/metabolismo; Subpopulações de Linfócitos T/imunologia; Subpopulações de Linfócitos T/metabolismo; Timócitos/imunologia; Timócitos/metabolismo; Testes de Função Tireóidea; Glândula Tireoide/imunologia; Glândula Tireoide/metabolismo; Glândula Tireoide/patologia; Fator A de Crescimento do Endotélio Vascular/metabolismo; Adulto Jovem

Palavras-chave

HIF-1α; Hashimoto's thyroiditis; NOX4; Sirtuin1; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Th1 / Estresse Oxidativo / Fator A de Crescimento do Endotélio Vascular / Doença de Hashimoto / Subunidade alfa do Fator 1 Induzível por Hipóxia / Sirtuína 1 Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article

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