S1PR1 signaling in cancer: A current perspective.

Anu, B; Namitha, N N; Harikumar, K B

Anu, B; Namitha, N N; Harikumar, K B.

Afiliação

Anu B; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, KL, India.
Namitha NN; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, KL, India.
Harikumar KB; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, KL, India. Electronic address: harikumar@rgcb.res.in.

Adv Protein Chem Struct Biol ; 125: 259-274, 2021.

Article em En | MEDLINE | ID: mdl-33931142

ABSTRACT

ABSTRACT

Sphingosine-1-phosphate receptor 1 (S1PR1) is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P). S1PR1 belongs to the sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). It has prominent roles in regulating endothelial cell cytoskeletal structure, cell migration, immunomodulation, vasculogenesis during embryogenesis, T cell egress and Multiple sclerosis. This review is addressing the role of S1PR1 in tumorigenesis and therapeutic opportunities to target S1PR1 in cancer.

Assuntos

Carcinogênese/imunologia; Proteínas de Neoplasias/imunologia; Neoplasias; Receptores de Esfingosina-1-Fosfato/imunologia; Animais; Humanos; Neoplasias/imunologia; Neoplasias/patologia; Neoplasias/terapia

Palavras-chave

Cancer; FTY720; Inflammation; Metastasis; Sphingosine kinase; Sphingosine-1-phosphate

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinogênese / Receptores de Esfingosina-1-Fosfato / Proteínas de Neoplasias / Neoplasias Limite: Animals / Humans Idioma: En Revista: Adv Protein Chem Struct Biol Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google