The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.

Jing, Xingzhi; Du, Ting; Li, Tao; Yang, Xiaoxia; Wang, Guodong; Liu, Xiaoyang; Jiang, Zhensong; Cui, Xingang

Jing, Xingzhi; Du, Ting; Li, Tao; Yang, Xiaoxia; Wang, Guodong; Liu, Xiaoyang; Jiang, Zhensong; Cui, Xingang.

Afiliação

Jing X; Department of spine surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Du T; Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital Affiliated to Shandong University, Jinan, China.
Li T; Department of spine surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Yang X; Department of spine surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Wang G; Department of spine surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Liu X; Department of spine surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Jiang Z; Department of spine surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Cui X; Department of spine surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

J Cell Mol Med ; 25(12): 5671-5680, 2021 06.

Article em En | MEDLINE | ID: mdl-33942503

Assuntos

Condrócitos/patologia; Citocinas/toxicidade; Mediadores da Inflamação/toxicidade; Inflamação/complicações; Sobrecarga de Ferro/complicações; Osteoartrite/patologia; Estresse Oxidativo; Animais; Células Cultivadas; Condrócitos/metabolismo; Masculino; Metaloproteinase 13 da Matriz/genética; Metaloproteinase 13 da Matriz/metabolismo; Metaloproteinase 3 da Matriz/genética; Metaloproteinase 3 da Matriz/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Osteoartrite/etiologia; Osteoartrite/metabolismo

Palavras-chave

iron overload; mitochondrial dysfunction; osteoarthritis; oxidative stress; pro-inflammatory cytokines

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Citocinas / Estresse Oxidativo / Mediadores da Inflamação / Sobrecarga de Ferro / Condrócitos / Inflamação Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: J Cell Mol Med Ano de publicação: 2021 Tipo de documento: Article

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