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The Multifaceted Roles of USP15 in Signal Transduction.
Das, Tanuza; Song, Eun Joo; Kim, Eunice EunKyeong.
Afiliação
  • Das T; Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02793, Korea.
  • Song EJ; Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
  • Kim EE; Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02793, Korea.
Int J Mol Sci ; 22(9)2021 Apr 29.
Article em En | MEDLINE | ID: mdl-33946990
Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Processamento de Proteína Pós-Traducional / Proteases Específicas de Ubiquitina Limite: Animals / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Processamento de Proteína Pós-Traducional / Proteases Específicas de Ubiquitina Limite: Animals / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article