Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia.
Can J Physiol Pharmacol
; 99(10): 1112-1113, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-33951396
ABSTRACT
Obstructive sleep apnea (OSA) is a chronic condition characterized by chronic intermittent hypoxia (IH) and is associated with cardiovascular (CVD) and chronic kidney diseases (CKD). Patients with OSA have increased biomarkers of aging such as telomere shortening. We used PCR to report shortened telomere lengths in aortic and renal tissues from mice exposed to 8 weeks of IH. Our data indicate that IH, a hallmark of OSA, accelerates vascular and renal aging that may contribute to OSA-induced CVD and CKD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta
/
Encurtamento do Telômero
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Rim
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Hipóxia
Limite:
Animals
Idioma:
En
Revista:
Can J Physiol Pharmacol
Ano de publicação:
2021
Tipo de documento:
Article