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Penetration of Singlet Oxygen into Films with Oxygen Permeability Coefficient Close to that of Skin.
Harada, Nobuyuki; Kataoka, Mika; Nakanosho, Masahiro; Uyama, Hiroshi.
Afiliação
  • Harada N; Nippon Shokubai Research Alliance Laboratories, Osaka University, Osaka, Japan.
  • Kataoka M; Nippon Shokubai Research Alliance Laboratories, Osaka University, Osaka, Japan.
  • Nakanosho M; Research Center, Nippon Shokubai Co. Ltd., Osaka, Japan.
  • Uyama H; Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, Japan.
Photochem Photobiol ; 97(5): 971-979, 2021 09.
Article em En | MEDLINE | ID: mdl-33973245
ABSTRACT
Although its antiviral and antibacterial functions help prevent infection, singlet oxygen (1 O2 )-which is generated by the action of light on an endogenous photosensitizer-is cytotoxic. In the present study, we investigated the ability of 1 O2 -generated by the action of visible light on a photosensitizer-to penetrate skin. We used two polymer films with oxygen permeability coefficients similar to that of skin-i.e. cellulose acetate (CA) and ethyl cellulose (EC). Both films contained 1,3-diphenylisobenzofuran (DPBF), which was used as an 1 O2 probe. 1 O2 generated externally did not permeate the films by mere contact. Therefore, we conclude that the potential for 1 O2 to penetrate the skin is very low, and films that generate 1 O2 are safe and useful for preventing infections by contact. We also proved that 1 O2 can move between the layers of integrated polymer films when they are joined together.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Oxigênio Singlete Idioma: En Revista: Photochem Photobiol Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigênio / Oxigênio Singlete Idioma: En Revista: Photochem Photobiol Ano de publicação: 2021 Tipo de documento: Article