Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model.

Lu-Nguyen, Ngoc; Malerba, Alberto; Herath, Shan; Dickson, George; Popplewell, Linda

Lu-Nguyen, Ngoc; Malerba, Alberto; Herath, Shan; Dickson, George; Popplewell, Linda.

Afiliação

Lu-Nguyen N; Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK.
Malerba A; Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK.
Herath S; Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK.
Dickson G; Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK.
Popplewell L; Department of Biological Sciences, School of Life Sciences and the Environment, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK.

Hum Mol Genet ; 30(15): 1398-1412, 2021 07 09.

Article em En | MEDLINE | ID: mdl-33987655

Assuntos

Proteínas de Homeodomínio/metabolismo; Distrofia Muscular Facioescapuloumeral/genética; Animais; Modelos Animais de Doenças; Genes Homeobox; Proteínas de Homeodomínio/genética; Humanos; Camundongos; Camundongos Transgênicos; Fibras Musculares Esqueléticas/metabolismo; Músculo Esquelético/metabolismo; Atrofia Muscular/genética; Distrofia Muscular Facioescapuloumeral/metabolismo; RNA Mensageiro/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Homeodomínio / Distrofia Muscular Facioescapuloumeral Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Ano de publicação: 2021 Tipo de documento: Article

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