The Diels-Alder Approach towards Cannabinoid Derivatives and Formal Synthesis of Tetrahydrocannabinol (THC).
ChemistryOpen
; 10(5): 587-592, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33988908
ABSTRACT
Based on the Diels-Alder reaction of vinylchromenes with electron-poor dienophiles, we developed a strategy for the synthesis of tetrahydrocannabinol derivatives. Substituted vinyl chromenes could be converted with several dienophiles to successfully isolate several complex molecules. These molecules already contain the cannabinoid-like base structure and further processing of one such derivative led to a precursor of Δ9 -tetrahydrocannabinol. The most challenging step towards this precursor was an epoxidation step that was ultimately achieved via dimethyl dioxirane.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dronabinol
/
Produtos Biológicos
/
Canabinoides
Idioma:
En
Revista:
ChemistryOpen
Ano de publicação:
2021
Tipo de documento:
Article