Incorporation of a Novel CD16-Specific Single-Domain Antibody into Multispecific Natural Killer Cell Engagers With Potent ADCC.

van Faassen, Henk; Jo, Dong-Hyeon; Ryan, Shannon; Lowden, Michael J; Raphael, Shalini; MacKenzie, C Roger; Lee, Seung-Hwan; Hussack, Greg; Henry, Kevin A

van Faassen, Henk; Jo, Dong-Hyeon; Ryan, Shannon; Lowden, Michael J; Raphael, Shalini; MacKenzie, C Roger; Lee, Seung-Hwan; Hussack, Greg; Henry, Kevin A.

Afiliação

van Faassen H; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
Jo DH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.
Ryan S; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
Lowden MJ; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
Raphael S; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
MacKenzie CR; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
Lee SH; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada.
Hussack G; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.
Henry KA; Human Health Therapeutics Research Centre, Life Sciences Division, National Research Council Canada, 100 Sussex Drive, Ottawa, Ontario K1A 0R6, Canada.

Mol Pharm ; 18(6): 2375-2384, 2021 06 07.

Article em En | MEDLINE | ID: mdl-33999642

Assuntos

Anticorpos Biespecíficos/metabolismo; Células Matadoras Naturais/transplante; Neoplasias/terapia; Proteínas Recombinantes de Fusão/metabolismo; Anticorpos de Domínio Único/metabolismo; Animais; Anticorpos Biespecíficos/genética; Citotoxicidade Celular Dependente de Anticorpos; Antígenos de Neoplasias/metabolismo; Bioensaio; Camelídeos Americanos; Proteínas Ligadas por GPI/antagonistas & inibidores; Proteínas Ligadas por GPI/genética; Humanos; Imunoterapia/métodos; Células Jurkat; Células Matadoras Naturais/metabolismo; Macaca fascicularis; Camundongos; Neoplasias/imunologia; Cultura Primária de Células; Domínios Proteicos/genética; Receptores de IgG/antagonistas & inibidores; Receptores de IgG/genética; Proteínas Recombinantes de Fusão/genética; Anticorpos de Domínio Único/genética

Palavras-chave

CD16; VHH; bispecific NK cell engager; cancer immunotherapy; nanobody; natural killer cell; single-domain antibody

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Células Matadoras Naturais / Anticorpos Biespecíficos / Anticorpos de Domínio Único / Neoplasias Limite: Animals / Humans Idioma: En Revista: Mol Pharm Ano de publicação: 2021 Tipo de documento: Article

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