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Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity.
Suzuki, Akinobu Z; Sakano, Taichi; Sasaki, Hirona; Watahiki, Rei; Sone, Masaki; Horikawa, Kazuki; Furuta, Toshiaki.
Afiliação
  • Suzuki AZ; Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp.
  • Sakano T; Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp.
  • Sasaki H; Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp.
  • Watahiki R; Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp.
  • Sone M; Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp.
  • Horikawa K; Department of Optical Imaging, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto Cho, Tokushima City, Tokushima 770-8503, Japan.
  • Furuta T; Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp.
Chem Commun (Camb) ; 57(46): 5630-5633, 2021 Jun 08.
Article em En | MEDLINE | ID: mdl-34018507
ABSTRACT
We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleotídeos Cíclicos Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleotídeos Cíclicos Limite: Humans Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2021 Tipo de documento: Article