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An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1).
Chiang, Shu-Fen; Huang, Kevin Chih-Yang; Chen, William Tzu-Liang; Chen, Tsung-Wei; Ke, Tao-Wei; Chao, K S Clifford.
Afiliação
  • Chiang SF; Laboratory of Precision Medicine, Ministry of Health & Welfare Feng Yuan Hospital, Taichung, Taiwan.
  • Huang KC; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
  • Chen WT; Translation Research Core, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Chen TW; Department of Colorectal Surgery, Hsinchu China Medical University Hospital, Hsinchu, Taiwan.
  • Ke TW; School of Medicine, China Medical University, Taichung Taiwan.
  • Chao KSC; Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Oncoimmunology ; 10(1): 1926074, 2021 05 14.
Article em En | MEDLINE | ID: mdl-34026338
Formyl peptide receptor 1 (FPR1) plays a key regulatory role in innate and adaptive immunity. Recently, we reported that the CC genotype of FPR1-E346A (rs867228, c. 1037 A > C) is an independent biomarker for patients with locally advanced rectal cancer (LARC) who received preoperative concurrent chemoradiotherapy (CCRT). Pharmacologic inhibition of FPR1 decreased the migration and infiltration of T lymphocytes into tumor microenvironment after CCRT.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Receptores de Formil Peptídeo Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Oncoimmunology Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Receptores de Formil Peptídeo Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Oncoimmunology Ano de publicação: 2021 Tipo de documento: Article