Geranylgeranyl pyrophosphate-mediated protein geranylgeranylation regulates endothelial cell proliferation and apoptosis during vasculogenesis in mouse embryo.

Chong, Danyang; Chen, Zhong; Guan, Shan; Zhang, Tongyu; Xu, Na; Zhao, Yue; Li, Chaojun

Chong, Danyang; Chen, Zhong; Guan, Shan; Zhang, Tongyu; Xu, Na; Zhao, Yue; Li, Chaojun.

Afiliação

Chong D; Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and School of Medicine, Nanjing University, National Resource Center for Mutant Mice, Nanjing 210093, China.
Chen Z; Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and School of Medicine, Nanjing University, National Resource Center for Mutant Mice, Nanjing 210093, China.
Guan S; Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and School of Medicine, Nanjing University, National Resource Center for Mutant Mice, Nanjing 210093, China.
Zhang T; Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and School of Medicine, Nanjing University, National Resource Center for Mutant Mice, Nanjing 210093, China.
Xu N; Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and School of Medicine, Nanjing University, National Resource Center for Mutant Mice, Nanjing 210093, China.
Zhao Y; Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and School of Medicine, Nanjing University, National Resource Center for Mutant Mice, Nanjing 210093, China. Electronic address: zhyue@nju.edu.cn.
Li C; Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and School of Medicine, Nanjing University, National Resource Center for Mutant Mice, Nanjing 210093, China. Electronic address: licj@nju.edu.cn.

J Genet Genomics ; 48(4): 300-311, 2021 04 20.

Article em En | MEDLINE | ID: mdl-34049800

Assuntos

Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Desenvolvimento Embrionário/genética; Farnesiltranstransferase/genética; Complexos Multienzimáticos/genética; Animais; Diferenciação Celular/efeitos dos fármacos; Embrião de Mamíferos; Células Endoteliais/efeitos dos fármacos; Células Endoteliais/metabolismo; Feminino; Camundongos; Morfogênese/genética; Fosfatos de Poli-Isoprenil/metabolismo; Fosfatos de Poli-Isoprenil/farmacologia; Gravidez; Prenilação de Proteína/efeitos dos fármacos; Prenilação de Proteína/genética; Proteínas de Sinalização YAP/genética; Proteína rhoA de Ligação ao GTP/genética

Palavras-chave

Apoptosis; Endothelial cell; GGPP; Proliferation; Protein geranylgeranylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Proliferação de Células / Desenvolvimento Embrionário / Farnesiltranstransferase / Complexos Multienzimáticos Limite: Animals / Pregnancy Idioma: En Revista: J Genet Genomics Ano de publicação: 2021 Tipo de documento: Article

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