Amide Bond Formation Using 4-Coumarate: CoA Ligase from Arabidopsis thaliana.
Chem Pharm Bull (Tokyo)
; 69(8): 717-720, 2021 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-34053981
ABSTRACT
Amide bond formation is one of the most fundamental reactions in organic chemistry, and amide bonds constitute the key functional groups in natural products, peptides, and pharmaceuticals. Here we demonstrate the chemoenzymatic syntheses of 4-coumaroyl- and hexanoyl-amino acids, using 4-coumarate CoA ligase from the model plant Arabidopsis thaliana (At4CL2). At4CL2 accepts 4-coumaric acid and hexanoic acid as the carboxylate substrates to generate acyl adenylates, which are captured by the amino group of amino acids to afford a series of N-acyl amides. This study shows the potential of 4CL for application as a biocatalyst to generate a series of biologically active amide compounds.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arabidopsis
/
Coenzima A
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Ácidos Cumáricos
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Amidas
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Ligases
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2021
Tipo de documento:
Article