A novel gene associated with small bowel bleeding in patients taking low-dose aspirin.
Dig Liver Dis
; 53(7): 841-845, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-34059446
ABSTRACT
OBJECTIVE:
We have previously revealed the clinical factors and genetic polymorphisms associated with gastrointestinal mucosal injury and bleeding, induced by low-dose aspirin (LDA). After performing genome-wide analysis of single nucleotide polymorphisms (SNPs) using the Drug Metabolizing Enzymes and Transporters (DMET) system among drug metabolism and transporter genes, certain SNPs were found to increase the risk for LDA-induced small bowel bleeding. The aim of this study was to identify the SNPs involved in LDA-induced small bowel bleeding. SUBJECTS ANDMETHODS:
Subjects were patients taking LDA, with small bowel bleeding diagnosed using capsule endoscopy. We investigated the clinical characteristics and the previously identified SNPs, that were examined by the DNA direct sequence method.RESULTS:
56 patients with bleeding and 410 controls taking LDA were enrolled. The risk factors associated with small bowel bleeding included smoking, cerebrovascular diseases, chronic renal failure, non-steroidal anti-inflammatory drug (NSAID) or anticoagulants combination, and two SNPs (CYP4F11 20043G>A (D446N) rs1060463, GSTP1 313A>G rs1695). After propensity score matching, GSTP1 rs1695 was significantly associated with small bowel bleeding.CONCLUSION:
The GSTP1 SNP may be a predictive marker for small bowel bleeding among patients taking LDA.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspirina
/
Glutationa S-Transferase pi
/
Família 4 do Citocromo P450
/
Variantes Farmacogenômicos
/
Hemorragia Gastrointestinal
/
Enteropatias
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Dig Liver Dis
Ano de publicação:
2021
Tipo de documento:
Article