Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach.
Transfus Apher Sci
; 60(3): 103162, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-34083162
ABSTRACT
Aging is associated with the impairment of stem cell activation, leading to the functional decline of tissues and increasing the risk for age-associated diseases. The old, damaged or unrepaired tissues disturb distant tissue homeostasis by secreting factors into the circulation, which may not only serve as biomarkers for specific age-associated pathologies but also induce a variety of degenerative phenotypes. In this review, we summarize and discuss systemic determinants that perpetuate age-related tissue dysfunction. We further elaborate on the effects of attenuating these circulating factors by highlighting recent advances which utilize plasmapheresis in a pre-clinical or clinical setting. Overall, we postulate that repositioning therapeutic plasma exchange (TPE) to dilute the systemic factors, which become deleterious at their age-elevated levels, could be a rapidly effective rejuvenation therapy that recalibrates crucial signaling pathways to a youthful state.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sangue
/
Plasmaferese
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Transfus Apher Sci
Ano de publicação:
2021
Tipo de documento:
Article