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Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.
Schmidt, Sven H; Weng, Jui-Hung; Aoto, Phillip C; Boassa, Daniela; Mathea, Sebastian; Silletti, Steve; Hu, Junru; Wallbott, Maximilian; Komives, Elizabeth A; Knapp, Stefan; Herberg, Friedrich W; Taylor, Susan S.
Afiliação
  • Schmidt SH; Department of Biochemistry, University of Kassel, 34132 Kassel, Germany.
  • Weng JH; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093.
  • Aoto PC; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093.
  • Boassa D; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093.
  • Mathea S; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093.
  • Silletti S; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093.
  • Hu J; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, D-60438 Frankfurt am Main, Germany.
  • Wallbott M; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093.
  • Komives EA; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093.
  • Knapp S; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093.
  • Herberg FW; Department of Biochemistry, University of Kassel, 34132 Kassel, Germany.
  • Taylor SS; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093.
Proc Natl Acad Sci U S A ; 118(23)2021 06 08.
Article em En | MEDLINE | ID: mdl-34088839
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação de Dinâmica Molecular / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação de Dinâmica Molecular / Serina-Treonina Proteína Quinase-2 com Repetições Ricas em Leucina Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article