The role of T cells in age-related diseases.
Nat Rev Immunol
; 22(2): 97-111, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34099898
ABSTRACT
Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that 'resetting' immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Revista:
Nat Rev Immunol
Ano de publicação:
2022
Tipo de documento:
Article