Feasible kidney donation with living marginal donors, including diabetes mellitus.
Immun Inflamm Dis
; 9(3): 1061-1068, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34102025
ABSTRACT
OBJECTIVES:
To compare the donor outcomes of living donor kidney transplantation between standard donors (SDs) and marginal donors (MDs) including diabetic patients (MD + DM).METHODS:
MDs were defined according to Japanese guideline criteria (a) age >70-years, (b) blood pressure ≤130/80 mmHg on hypertension medicine, (c) body mass index >25 to ≤32 kg/m2 , (d) 24-h creatinine clearance ≥70 to <80 ml/min/1.73 m2 , and (e) hemoglobin A1c > 6.2 or ≤6.5 with oral diabetic medicine. Fifty-three of 114 donors were MDs. We compared donor kidney functions until 60 months postoperatively.RESULTS:
No kidney function parameters were different between SDs and MDs. When comparing SD and MD + DM, MD + DM had a lower postoperative eGFR (48 vs. 41 (1 (month), p = .02), 49 vs. 40 (12, p < .01), 48 vs. 42 (24, p = .04), 47 vs. 38 (36, p = .01)) and the percentage of residual eGFR (SD vs. MD + DM 63 vs. 57 (1 (month), p < .01), 63 vs. 57 (2, p < .01), 64 vs. 56 (12, p < .01), 63 vs. 57 (24, p < .01), 63 vs. 52 (36, p = .02)). However, when MD with a single risk factor of DM was compared to SD, the difference disappeared. Nine out of 12 (75%) MD + DM had ≥2 risk factors.CONCLUSIONS:
Although long-term observation of donor kidney function is necessary, careful MD + DM selection had the potential to expand the donor pool.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Diabetes Mellitus
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
Immun Inflamm Dis
Ano de publicação:
2021
Tipo de documento:
Article