Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents.
ChemMedChem
; 16(18): 2781-2785, 2021 09 16.
Article
em En
| MEDLINE
| ID: mdl-34115919
ABSTRACT
Several naturally occurring cyclopentenones, such as palmenones and nigrosporiones, exhibit antimicrobial activity. Herein we describe the antimicrobial activity of cyclopentenones and derivatives that can be easily accessed from biomass derivatives furfural and 5-hydroxymethylfurfural. Upon screening a range of functionalized trans-diamino-cyclopentenones (DCPs) and δ-lactone-fused cyclopentenones (LCPs), an oxime ether derivative of DCP was identified that exhibited remarkable antimicrobial activity against Gram-positive bacteria, including resistant strains such as methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecalis (VRE) strains.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
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Enterococcus faecalis
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Ciclopentanos
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Éter
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Staphylococcus aureus Resistente à Meticilina
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Antibacterianos
Idioma:
En
Revista:
ChemMedChem
Ano de publicação:
2021
Tipo de documento:
Article