Bis(ethylmaltolato)oxidovanadium (IV) attenuates amyloid-beta-mediated neuroinflammation by inhibiting NF-&#954;B signaling pathway via a PPARÎ³-dependent mechanism.

He, Zhijun; Li, Xiaoqian; Han, Shuangxue; Ren, Bingyu; Hu, Xia; Li, Nan; Du, Xiubo; Ni, Jiazuan; Yang, Xiaogai; Liu, Qiong

Bis(ethylmaltolato)oxidovanadium (IV) attenuates amyloid-beta-mediated neuroinflammation by inhibiting NF-κB signaling pathway via a PPARÎ³-dependent mechanism.

He, Zhijun; Li, Xiaoqian; Han, Shuangxue; Ren, Bingyu; Hu, Xia; Li, Nan; Du, Xiubo; Ni, Jiazuan; Yang, Xiaogai; Liu, Qiong.

Afiliação

He Z; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China.
Li X; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Han S; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China.
Ren B; College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430073, China.
Hu X; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China.
Li N; College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430073, China.
Du X; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China.
Ni J; Shenzhen Bay Laboratory, Shenzhen, 518055, China.
Yang X; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong, 518060, China.
Liu Q; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China.

Metallomics ; 13(7)2021 07 02.

Article em En | MEDLINE | ID: mdl-34124763

Assuntos

Doença de Alzheimer/prevenção & controle; Peptídeos beta-Amiloides/toxicidade; NF-kappa B/antagonistas & inibidores; Doenças Neuroinflamatórias/prevenção & controle; Fármacos Neuroprotetores/farmacologia; Compostos Organometálicos/farmacologia; PPAR gama/metabolismo; Doença de Alzheimer/etiologia; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Animais; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Microglia/efeitos dos fármacos; Microglia/metabolismo; Microglia/patologia; NF-kappa B/genética; NF-kappa B/metabolismo; Doenças Neuroinflamatórias/etiologia; Doenças Neuroinflamatórias/metabolismo; Doenças Neuroinflamatórias/patologia; PPAR gama/genética

Palavras-chave

Alzheimer's disease (AD); amyloid-beta (Aß); bis(ethylmaltolato)oxidovanadium (BEOV) (IV); neuroinflammation; nuclear factor-κB (NF-κB); peroxisome proliferator-activated receptor gamma (PPARÎ³)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Peptídeos beta-Amiloides / NF-kappa B / Fármacos Neuroprotetores / PPAR gama / Doença de Alzheimer / Doenças Neuroinflamatórias Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Metallomics Ano de publicação: 2021 Tipo de documento: Article

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