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Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic.
Huang, Huoming; Li, Xueping; Xie, Peng; Li, Xinwei; Xu, XueJun; Qian, Yuanyuan; Yuan, Congmin; Meng, Xiangguo; Chai, JingRui; Chen, Jing; Liu, Jing; Wang, Wenli; Li, Wei; Wang, YuJun; Fu, Wei; Liu, Jinggen.
Afiliação
  • Huang H; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Li X; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Xie P; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China.
  • Li X; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Xu X; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Qian Y; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Yuan C; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Meng X; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Chai J; School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
  • Chen J; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Liu J; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Wang W; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Li W; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China.
  • Wang Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Fu W; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • Liu J; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
J Med Chem ; 64(13): 9458-9483, 2021 07 08.
Article em En | MEDLINE | ID: mdl-34152138
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Receptores Opioides mu / Descoberta de Drogas / Analgésicos Opioides Limite: Animals Idioma: En Revista: J Med Chem Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Receptores Opioides mu / Descoberta de Drogas / Analgésicos Opioides Limite: Animals Idioma: En Revista: J Med Chem Ano de publicação: 2021 Tipo de documento: Article