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Gene Expression Profiling in the Skin Reveals Strong Similarities between Subacute and Chronic Cutaneous Lupus that Are Distinct from Lupus Nephritis.
Ko, Wei-Che C; Li, Li; Young, Taylor R; McLean-Mandell, Riley E; Deng, April C; Vanguri, Vijay K; Dresser, Karen; Harris, John E.
Afiliação
  • Ko WC; Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Li L; Computational Biology, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA.
  • Young TR; Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • McLean-Mandell RE; Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Deng AC; Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Vanguri VK; Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Dresser K; Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Harris JE; Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Electronic address: john.harris@umassmed.edu.
J Invest Dermatol ; 141(12): 2808-2819, 2021 12.
Article em En | MEDLINE | ID: mdl-34153327
ABSTRACT
Subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus are represented in the majority of cutaneous lupus subtypes, each of which has variable implications for systemic manifestations such as lupus nephritis. On dermatologic examination, subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus are distinct. However, it is often difficult to diagnose the subtype from histology alone. Our study utilized whole-genome microarray expression analysis on human skin samples of subacute cutaneous lupus erythematosus, on human skin samples of chronic cutaneous lupus erythematosus, and on healthy controls, along with analysis on human samples of lupus nephritis and normal kidney tissue to compare cutaneous lupus subtypes with each other as well as with lupus nephritis. The data revealed that cutaneous lupus subtypes were distinct from healthy control skin, with gene expression predominantly characterized by upregulation of IFN-1 and T-cell chemotactic genes. However, the cutaneous lupus subtypes were very similar to one another; comparative analyses revealed few statistically significant differences in gene expression. There were also distinct differences between the gene signatures of cutaneous lupus and lupus nephritis. Cutaneous lupus samples revealed gene signatures demonstrating a prominent inflammatory component that may suggest the skin as an early site of initiation of lupus pathogenesis, whereas lupus nephritis reflected the recruitment and activation of M2 macrophages and a wound healing signature.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Lúpus Eritematoso Cutâneo / Nefrite Lúpica / Lúpus Eritematoso Discoide / Perfilação da Expressão Gênica Limite: Humans Idioma: En Revista: J Invest Dermatol Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Lúpus Eritematoso Cutâneo / Nefrite Lúpica / Lúpus Eritematoso Discoide / Perfilação da Expressão Gênica Limite: Humans Idioma: En Revista: J Invest Dermatol Ano de publicação: 2021 Tipo de documento: Article