Genetic Analysis in Anal and Cervical Cancer: Exploratory Findings About Radioresistance in the ProfiLER Database.
Cancer Genomics Proteomics
; 18(4): 515-520, 2021.
Article
em En
| MEDLINE
| ID: mdl-34183384
ABSTRACT
BACKGROUND/AIM:
This study aimed to describe genomic alterations on squamous cell cervical and anal carcinomas. MATERIALS ANDMETHODS:
From 2013 to 2019, 3,269 patients were included in the molecular screening ProfiLER trial. Only patients with non-metastatic cervical or anal cancer, and those initially treated with radiotherapy in a curative intent were selected. Genetic analyses were performed by next generation sequencing (NGS).RESULTS:
Genomic alterations were observed in most patients 5 patients out of 15 (33.3%) had at least one mutation on NGS and 4 out of 15 (26.7%) had at least one aberration of the number of copies of genes in the comparative genomic hybridation (CGH) analysis. The most common mutated gene was PIK3CA.CONCLUSION:
All omic approaches must be integrated in the locally advanced cancer setting by new clinical trial design to develop two routes in the treatment strategy intensification or de-escalation treatment strategy according to omic markers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Ânus
/
Tolerância a Radiação
/
Carcinoma de Células Escamosas
/
Neoplasias do Colo do Útero
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Genomics Proteomics
Ano de publicação:
2021
Tipo de documento:
Article