Severe thrombocytopenia is sufficient for fetal and neonatal intracerebral hemorrhage to occur.
Blood
; 138(10): 885-897, 2021 09 09.
Article
em En
| MEDLINE
| ID: mdl-34189583
ABSTRACT
Intracerebral hemorrhage (ICH) has a devastating impact on the neonatal population. Whether thrombocytopenia is sufficient to cause ICH in neonates is still being debated. In this study, we comprehensively investigated the consequences of severe thrombocytopenia on the integrity of the cerebral vasculature by using 2 orthogonal approaches by studying embryogenesis in the Nfe2-/- mouse line and by using biologics (anti-GP1Bα antibodies) to induce severe thrombocytopenia at defined times during development. By using a mouse model, we acquired data demonstrating that platelets are required throughout fetal development and into neonatal life for maintaining the integrity of the cerebral vasculature to prevent hemorrhage and that the location of cerebral hemorrhage is dependent on when thrombocytopenia occurs during development. Importantly, this study demonstrates that fetal and neonatal thrombocytopenia-associated ICH occurs within regions of the brain which, in humans, could lead to neurologic damage.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombocitopenia
/
Hemorragia Cerebral
/
Feto
Aspecto:
Patient_preference
Limite:
Animals
Idioma:
En
Revista:
Blood
Ano de publicação:
2021
Tipo de documento:
Article