Intracranial haemorrhage associated with Vitamin K deficiency in Egyptian infants.
Acta Paediatr
; 110(11): 2937-2943, 2021 Nov.
Article
em En
| MEDLINE
| ID: mdl-34196053
ABSTRACT
AIM:
Intracranial haemorrhage (ICH) in infancy is a rare life-threatening event. The aim of this review is to highlight the association of ICH and potentially preventable vitamin K deficiency and to describe risk factors, presentation and outcome.METHODS:
Original published data on ICH related to vitamin K deficiency during 2008-2012 were extracted from records of participating centres in Egypt (Cairo and Delta region). Full data on 70 infants (0-24 weeks) have been reported in three publications.RESULTS:
The first study involved premature infants where ICH was potentially preventable with administration of parenteral vitamin K prophylactic doses to mothers ahead of imminent preterm delivery. The other 2 studies involved term newborns and infants. ICH due to early or classic vitamin K deficiency was reported in nine patients while 44 were due to late vitamin K deficiency. Main risk factors for late onset were exclusive breastfeeding, persistent diarrhoea and/or prolonged antibiotic therapy.CONCLUSION:
Vitamin K deficiency bleeding is a relatively frequent problem underlying ICH in infancy. Prophylactic vitamin K to mothers when anticipating preterm labour or a vitamin K boost in exclusively breast-fed infants with prolonged antibiotic usage and, or, persistent diarrhoea might have an impact on prevention and outcome.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Sangramento por Deficiência de Vitamina K
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Infant
/
Newborn
País/Região como assunto:
Africa
Idioma:
En
Revista:
Acta Paediatr
Ano de publicação:
2021
Tipo de documento:
Article